Term Name
maturity-onset diabetes of the young type 2
External Reference
Synonyms
MODY, type II, glucokinase-associated diabetes mellitus, MODY 2 monogenic diabetes type 2, MODY glucokinase-related, GCK-associated diabetes mellitus, MODY2, GCK maturity-onset diabetes of the young (disease), maturity onset diabetes of the Young, type 2, maturity-onset diabetes of the young (disease) caused by mutation in GCK, MODY type 2
Definition
Monogenic diabetes caused by inactivating mutation(s) in the GCK gene, encoding glucokinase. Heterozygous GCK mutations may manifest as mild hyperglycemia, which is not progressive, and usually requires no treatment. Homozygous GCK mutations result in permanent neonatal diabetes.