Term Name
maturity-onset diabetes of the young type 2
External Reference
Synonyms
maturity-onset diabetes of the young (disease) caused by mutation in GCK, MODY type 2, MODY, type II, MODY glucokinase-related, glucokinase-associated diabetes mellitus, GCK-associated diabetes mellitus, MODY 2 monogenic diabetes type 2, MODY2, GCK maturity-onset diabetes of the young (disease), maturity onset diabetes of the Young, type 2
Definition
Monogenic diabetes caused by inactivating mutation(s) in the GCK gene, encoding glucokinase. Heterozygous GCK mutations may manifest as mild hyperglycemia, which is not progressive, and usually requires no treatment. Homozygous GCK mutations result in permanent neonatal diabetes.